Structure via PubChem · Public domain (PubChem)
desonide
Sign in to saveAlso known as D-2083, Desowen®, desfluorotriamcinolone acetonide, 11beta,21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione, 16alpha,17alpha-isopropylidenedioxyprednisolone, 11beta,21-dihydroxy-16alpha,17-isopropylidenedioxypregna-1,4-diene-3,20-dione, 16alpha-hydroxyprednisolone-16alpha,17-acetonide, 11beta,21-dihydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Desonide (INN) is a low-potency topical corticosteroid anti-inflammatory that has been available since the 1970s. It is primarily used to treat atopic dermatitis (eczema), seborrheic dermatitis, contact dermatitis and psoriasis in both adults and children. It has a fairly good safety profile and is available as a cream, ointment, lotion, and as a foam under the tradename Verdeso Foam. Other trade names for creams, lotions, and ointments include Tridesilon, DesOwen, Desonate. It is a group VI corticosteroid under US classification, the second least potent group.
Chemical data
- Formula
- C24H32O6
- Molecular weight
- 416.5 g/mol
- IUPAC name
- (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
- SMILES
- C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@]35C)O
- InChIKey
- WBGKWQHBNHJJPZ-LECWWXJVSA-N
- XLogP
- 2.7
- Polar surface area
- 93.1 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1972
- Admin. routes
- topical
- Indications
- eye inflammation, atopic eczema, skin disease
via ChEMBL · EBI
Research
173 papers- Desonide.2006
- Desonide foam: a review.Drugs of today (Barcelona, Spain : 1998) · 2008
- Desonide: a review of formulations, efficacy and safety.Expert opinion on investigational drugs · 2008
- Desonide Nanoemulsion Gel for Transdermal Absorption Drug Delivery: Pharmacodynamic and Safety Evaluation.Current drug delivery · 2023
- Overview on desonide 0.05%: a clinical safety profile.Journal of drugs in dermatology : JDD · 2004
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 416.22
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₄H₃₂O₆
- subject has role
- anti-inflammatory agent
- medical condition treated
- seborrhoeic dermatitis
- isomeric SMILES
- C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@]35C)O
- canonical SMILES
- CC1(OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C)C
- World Health Organisation international non-proprietary name
- desonide
- Commons category
- Desonide
via Wikidata · CC0
~8 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Adverse effects
- Pregnancy
- Breastfeeding
- Mechanism of action
- Interactions
- History
- Research and clinical trials
- Regulatory
- References
Desonide (INN) is a low-potency topical corticosteroid anti-inflammatory that has been available since the 1970s. It is primarily used to treat atopic dermatitis (eczema), seborrheic dermatitis, contact dermatitis and psoriasis in both adults and children. It has a fairly good safety profile and is available as a cream, ointment, lotion, and as a foam under the tradename Verdeso Foam. Other trade names for creams, lotions, and ointments include Tridesilon, DesOwen, Desonate. It is a group VI corticosteroid under US classification, the second least potent group.
==Medical uses== Desonide is a prescription topical treatment for redness, swelling, itching, and discomfort of various skin conditions. Regardless of the vehicle used, desonide is applied 2 to 3 times a day, at the same times each day. Skin conditions typically improve in the first two weeks of treatment. Patients are instructed to use desonide for the minimum amount of time necessary for conditions to improve.
Excerpted from Wikipedia’s “desonide” article, available under the CC BY-SA 4.0 licence.