Structure via PubChem · Public domain (PubChem)
difluprednate
Sign in to saveAlso known as DFBA, Durezol®, W-6309, Difluoroprednisolone butyrate acetate
Difluprednate, sold under the brand name Durezol, is a corticosteroid used for the treatment of post-operative ocular inflammation and pain.
Chemical data
- Formula
- C27H34F2O7
- Molecular weight
- 508.5 g/mol
- IUPAC name
- [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
- SMILES
- CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C(=O)COC(=O)C
- InChIKey
- WYQPLTPSGFELIB-JTQPXKBDSA-N
- XLogP
- 3.4
- Polar surface area
- 107 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2008
- Admin. routes
- topical
- Indications
- dry eye syndrome, anterior uveitis, inflammation, uveitis
via ChEMBL · EBI
Research
193 papers- Difluprednate.2006
- Difluprednate versus Prednisolone Acetate after Cataract Surgery: a Systematic Review and Meta-Analysis.BMJ open · 2019
- Difluprednate for inflammatory eye disorders.Drugs of today (Barcelona, Spain : 1998) · 2011
- Outcomes of difluprednate treatment for corneal graft rejection.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2020
- Effectiveness of difluprednate in addition to systemic therapy for the treatment of anterior scleritis.The British journal of ophthalmology · 2024
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 508.227
- Manufacturer
- Novartis
- Has use
- medication
Show 6 more facts
- chemical formula
- C₂₇H₃₄F₂O₇
- subject has role
- glucocorticoid
- medical condition treated
- eye disease
- canonical SMILES
- CCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C
- isomeric SMILES
- CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C(=O)COC(=O)C
- Commons category
- Difluprednate
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Medical uses
- Clinical trials
- References
Difluprednate, sold under the brand name Durezol, is a corticosteroid used for the treatment of post-operative ocular inflammation and pain.
It was approved for medical use in the United States in June 2008. It is available as a generic medication.
Excerpted from Wikipedia’s “difluprednate” article, available under the CC BY-SA 4.0 licence.