DMAC2
Sign in to saveAlso known as ATP5SL, ATP5S like, distal membrane arm assembly complex 2, distal membrane arm assembly component 2
ATP synthase subunit s-like protein is a protein that in humans is encoded by the DMAC2 gene. It has a role in the assembly of the distal portion of the Mitochondiral Respiratory Complex 1 (NADH: ubiquinone oxidoreductase) membrane arm. Complex 1 is the largest respiratory complex of the mitochondrial electron transport chain. == Gene == ATP5SL’s preferred name is DMAC2, Distal membrane arm assembly complex 2. DMAC2 is on the minus strand of Chromosome 19 and spans 9400 base pairs. == mRNA == There are 6 exons within ATP5SL's mRNA sequence and 12 known transcript variants that span between 148
Gene data
DMAC2- Name
- distal membrane arm assembly component 2
- Type
- protein-coding
- Aliases
- ATP5SL
Involved in mitochondrial respiratory chain complex I assembly. Colocalizes with mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
distal membrane arm assembly component 2
- Symbol
- DMAC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:41,431,317-41,440,717
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 9973
- exact match
- identifiers.org/ncbigene/55101
- genomic start
- 41937223
- genomic end
- 41946622
- cytogenetic location
- 19q13.2
Sources (3)
via Wikidata · CC0
~10 min read
Article
16 sectionsContents
- Gene
- mRNA
- Expression
- Protein
- Amino Acid Composition
- Regions
- Post-translational modification
- Protein Structure
- Protein Interactions
- Conceptual translation
- Homology
- Clinical Significance
- SNPs
- References
- External links
- Further reading
ATP synthase subunit s-like protein is a protein that in humans is encoded by the DMAC2 gene. It has a role in the assembly of the distal portion of the Mitochondiral Respiratory Complex 1 (NADH: ubiquinone oxidoreductase) membrane arm. Complex 1 is the largest respiratory complex of the mitochondrial electron transport chain. == Gene == ATP5SL’s preferred name is DMAC2, Distal membrane arm assembly complex 2. DMAC2 is on the minus strand of Chromosome 19 and spans 9400 base pairs. == mRNA == There are 6 exons within ATP5SL's mRNA sequence and 12 known transcript variants that span between 1489 and 2515 nucleotides.
The 3' untranslated region sequence has 8 large stem loops with 3 overlapping miRNA target binding sites: hsa-miR-4731-5p, hsa-miR-671-5p, and hsa-miR-4786-3p. This site is almost fully conserved in primates; it differs by one base pair. A secondary site of hsa-miR-4731-5p is fully conserved among Primates.