DNA replication factor A complex

Also known as GO:0005662, RPA, replication protein A, Replication protein A

conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism

Research

963 papers

Regulated eukaryotic DNA replication origin firing with purified proteins.Nature · 2015
Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.Cell · 2023
Replication protein A complex in Thermococcus kodakarensis interacts with DNA polymerases and helps their effective strand synthesis.Bioscience, biotechnology, and biochemistry · 2019
The human primosome requires replication protein A when copying DNA with inverted repeats.Nucleic acids research · 2025
Partial Purification of a Megadalton DNA Replication Complex by Free Flow Electrophoresis.PloS one · 2016

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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).

Eukaryotic DNA replication

general transcription factor IIB

DNA replication factor A complex

Research

Available in 11 languages

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