DPP6
Sign in to saveAlso known as DPPX, VF2, MRD33, DPL1, dipeptidyl peptidase like 6
Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.
Gene data
DPP6- Name
- dipeptidyl peptidase like 6
- Type
- protein-coding
- Aliases
- DPL1, DPPX, MRD33, VF2
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
via MyGene.info
Gene · Ensembl
dipeptidyl peptidase like 6
- Symbol
- DPP6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:153,748,133-154,894,285
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein DPP6 PDB 1xfd.png
Show 5 more facts
- HomoloGene ID
- 22560
- exact match
- identifiers.org/ncbigene/1804
- genomic start
- 153584182
- genomic end
- 154685995
- cytogenetic location
- 7q36.2
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.