DPP6

Also known as DPPX, VF2, MRD33, DPL1, dipeptidyl peptidase like 6

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.

In the Vinony graph

Within Vinony's link graph, DPP6 is referenced by 17 other articles, and connects out to PubMed, human chromosome 7 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 7.

Its subject is documented across 5 Wikipedia language editions.

Gene data

DPP6

Name: dipeptidyl peptidase like 6
Type: protein-coding
Position: 153,748,133–154,894,285 (+)
Aliases: DPL1, DPPX, MRD33, VF2
Ensembl: ENSG00000130226
RefSeq RNA: NM_001039350.3, NM_001290252.2, NM_001290253.2, NM_001364497.2, NM_001364498.2
RefSeq protein: NP_001034439.1, NP_001277181.1, NP_001277182.1, NP_001351426.1, NP_001351427.1

This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].

Gene Ontology

Biological process

proteolysis protein localization to plasma membrane regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport

Molecular function

protein binding serine-type peptidase activity dipeptidyl-peptidase activity potassium channel regulator activity potassium channel regulator activity potassium channel regulator activity

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane voltage-gated potassium channel complex voltage-gated potassium channel complex membrane

via MyGene.info

Gene · Ensembl

dipeptidyl peptidase like 6

Symbol: DPP6
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:153,748,133-154,894,285
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein DPP6 PDB 1xfd.png

Show 7 more facts

HomoloGene ID: 22560
chromosome: human chromosome 7
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1804
genomic start: 153584182
genomic end: 154685995
cytogenetic location: 7q36.2

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Excerpted from Wikipedia’s “DPP6” article, available under the CC BY-SA 4.0 licence.