entinostat

Also known as MS-275, SNDX-275, N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester, BAY86-5274, MS 275, MS 27-275, BAY 86-5274, MS-27-275

Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers.

In the Vinony graph

Vinony's link graph records 310 inbound references to entinostat, and connects out to valproic acid, sodium phenylbutyrate and tiazofurin.

It is catalogued under topics including 2-Aminophenyl compounds, 3-Pyridyl compounds and Benzamides.

Vinony links it to 7 Wikipedia language editions.

Chemical data

Formula: C21H20N4O3
Molecular weight: 376.4 g/mol
IUPAC name: pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3
InChIKey: INVTYAOGFAGBOE-UHFFFAOYSA-N
XLogP: 2
Polar surface area: 106 Å²
H-bond donors: 3
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: Hodgkins lymphoma, breast carcinoma, myelodysplastic syndrome, acute myeloid leukemia

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 376.153541
Has use: medication

Show 5 more facts

chemical formula: C₂₁H₂₀N₄O₃
canonical SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3
World Health Organisation international non-proprietary name: entinostat
subject has role: antineoplastic
Commons category: Entinostat

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References

{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 444340516 | ImageFile = Entinostat.svg | ImageClass = skin-invert-image | ImageSize = 260 | PIN = (Pyridin-3-yl)methyl ({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate | OtherNames = SNDX-275; MS-275 |Section1= |Section2= |Section3= | Section5 = }}

Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers.

Excerpted from Wikipedia’s “entinostat” article, available under the CC BY-SA 4.0 licence.