epanolol
Also known as ICI 141292
Epanolol is a beta blocker. developed by Imperial Chemical Industries. ==Synthesis== upright=2 The ester methyl 4-benzyloxyphenylacetate (1) is treated with ethylenediamine to give the amide (3). Separately, 2-cyanophenol (4) is reacted with epichlorohydrin and sodium hydroxide to produce the benzonitrile derivative (5). Combination of (3) and (5) by heating in propanol gives (6). Lastly, catalytic hydrogenation removes the benzyl protecting group and yields epanolol.
Research
58 papers- Clinical pharmacology of epanolol. Pharmacodynamic aspects.Drugs · 1989
- An overview of clinical trial experience with epanolol.Drugs · 1989
- Epanolol. A new once-daily antianginal agent: dose finding and long term efficacy.Drugs · 1989
- Efficacy of epanolol versus metoprolol in angina pectoris: report from a Swedish multicentre study of exercise tolerance.Journal of internal medicine · 1992
- Effects of epanolol and metoprolol on the heart measured by 24-hour holter monitoring.Drugs · 1989
via PubMed
Article
3 sectionsContents
- Synthesis
- See also
- References
Epanolol is a beta blocker. developed by Imperial Chemical Industries. ==Synthesis== upright=2 The ester methyl 4-benzyloxyphenylacetate (1) is treated with ethylenediamine to give the amide (3). Separately, 2-cyanophenol (4) is reacted with epichlorohydrin and sodium hydroxide to produce the benzonitrile derivative (5). Combination of (3) and (5) by heating in propanol gives (6). Lastly, catalytic hydrogenation removes the benzyl protecting group and yields epanolol.
==See also== Bunitrolol Bucindolol