FHIT

Also known as AP3Aase, FRA3B, fragile histidine triad, tríada histidina fràgil, fragile histidine triad diadenosine triphosphatase

'''Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein' (FHIT) is an enzyme that in humans is encoded by the FHIT'' gene.

In the Vinony graph

Vinony's link graph records 8 inbound references to FHIT, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 3.

Vinony links it to 5 Wikipedia language editions.

Gene data

FHIT

Name: fragile histidine triad diadenosine triphosphatase
Type: protein-coding
Position: 59,747,277–61,251,466 (−)
Aliases: AP3Aase, FRA3B
Ensembl: ENSG00000189283
RefSeq RNA: NM_001166243.3, NM_001320899.2, NM_001320900.2, NM_001320901.2, NM_001354589.2
RefSeq protein: NP_001159715.1, NP_001307828.1, NP_001307829.1, NP_001307830.1, NP_001341518.1

The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017].