finerenone

Also known as BAY 94-8862

Finerenone, marketed under the brand name Kerendia among others, is a medication used to reduce the risk of kidney function decline, kidney failure, cardiovascular death, non-fatal, non-fatal myocardial infarctions, and hospitalization for heart failure in adults with chronic kidney disease associated with type2 diabetes. In the United States, it is also approved to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in adults with heart failure and a left ventricular ejection fraction (LVEF) of 40% or greater. Finerenone is a non-steroid

Key facts

Drug.image: Finerenone.svg
Drug.image_class: skin-invert-image
Drug.tradename: Kerendia
Drug.MedlinePlus: a621038
Drug.DailyMedID: Finerenone
Drug.pregnancy_AU: D
Drug.routes_of_administration: Oral
Drug.class: Potassium-sparing diuretic
Drug.ATC_prefix: C03
Drug.ATC_suffix: DA05
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.CAS_number: 1050477-31-0
Drug.PubChem: 60150535
Drug.DrugBank: DB16165
Drug.ChemSpiderID: 28669387

via Wikipedia infobox

Wikidata facts

Subclass of: chemical compound
Mass: 378.169191

Show 5 more facts

chemical formula: C₂₁H₂₂N₄O₃
isomeric SMILES: CCOC1=NC=C(C2=C1[C@@H](C(=C(N2)C)C(=O)N)C3=C(C=C(C=C3)C#N)OC)C
canonical SMILES: CCOC1=NC=C(C2=C1C(C(=C(N2)C)C(=O)N)C3=C(C=C(C=C3)C#N)OC)C
physically interacts with: Nuclear receptor subfamily 3 group C member 2
Commons category: Finerenone

Sources (3)

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Encyclopedic overview

9 sections

Contents

Medical uses
Pharmacology
Adverse effects
History
Legal status
Brand names
Research
References
Further reading

Common side effects include abnormally high levels of potassium in the bloodstream, abnormally low levels of sodium in the bloodstream, and abnormally low blood pressure.

Excerpted from Wikipedia’s “finerenone” article, available under the CC BY-SA 4.0 licence.

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