Structure via PubChem · Public domain (PubChem)
flecainide
Sign in to saveAlso known as Tambocor®, Flecaine, N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide, CCRIS 313, (+-)-flecainide, (+-)-Flecainide, Flecainida
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. Its use is only recommended in those with dangerous arrhythmias or when significant symptoms cannot be managed with other treatments. Its use does not decrease a person's risk of death. It is taken by mouth or injection into a vein.
Chemical data
- Formula
- C17H20F6N2O3
- Molecular weight
- 414.34 g/mol
- IUPAC name
- N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
- SMILES
- C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)F
- InChIKey
- DJBNUMBKLMJRSA-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 59.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1985
- Admin. routes
- oral
- Indications
- atrial fibrillation, cardiac arrhythmia, Arrhythmogenic right ventricular dysplasia
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 414.138
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₇H₂₀F₆N₂O₃
- significant drug interaction
- darifenacin
- canonical SMILES
- C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)F
- World Health Organisation international non-proprietary name
- flecainide
- medical condition treated
- atrial fibrillation
- Commons category
- Flecainide
- legal status (medicine)
- boxed warning
Sources (6)
via Wikidata · CC0
~7 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Side effects
- Treatment
- Lungs
- Interactions
- Overdose
- Mechanism of action
- Society and culture
- Brand names
- References
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. Its use is only recommended in those with dangerous arrhythmias or when significant symptoms cannot be managed with other treatments. Its use does not decrease a person's risk of death. It is taken by mouth or injection into a vein.
Common side effects include dizziness, problems seeing, shortness of breath, chest pain, and tiredness. Serious side effects may include cardiac arrest, arrhythmias, and heart failure. It may be used in pregnancy, but has not been well studied in this population. Use is not recommended in those with structural heart disease or ischemic heart disease. Flecainide is a class Ic antiarrhythmic agent. It works by decreasing the entry of sodium in heart cells, causing prolongation of the cardiac action potential.
Excerpted from Wikipedia’s “flecainide” article, available under the CC BY-SA 4.0 licence.