Structure via PubChem · Public domain (PubChem)
darifenacin
Sign in to saveAlso known as DAR328, UK-88525, (S)-1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-alpha,alpha-diphenyl-3-pyrrolidineacetamide
Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. It was discovered by scientists at the Pfizer research site in Sandwich, UK under the identifier UK-88,525 and used to be marketed by Novartis. In 2010, the US rights were sold to Warner Chilcott for .
Chemical data
- Formula
- C28H30N2O2
- Molecular weight
- 426.5 g/mol
- IUPAC name
- 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
- SMILES
- C1CN(C[C@@H]1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5
- InChIKey
- HXGBXQDTNZMWGS-RUZDIDTESA-N
- XLogP
- 4.6
- Polar surface area
- 55.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2004
- Admin. routes
- oral
- Indications
- overactive bladder, Urinary incontinence, Polyuria, amyotrophic lateral sclerosis
via ChEMBL · EBI
Wikidata facts
- Mass
- 426.231
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₈H₃₀N₂O₂
- defined daily dose
- 7.5
- Commons category
- Darifenacin
- isomeric SMILES
- C1CN(C[C@@H]1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5
- canonical SMILES
- C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5
- World Health Organisation international non-proprietary name
- darifenacin
- significant drug interaction
- flecainide
Sources (5)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Adverse effects
- Medical uses
- Mechanism of action
- References
- External links
Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. It was discovered by scientists at the Pfizer research site in Sandwich, UK under the identifier UK-88,525 and used to be marketed by Novartis. In 2010, the US rights were sold to Warner Chilcott for .
== Adverse effects == Darifenacin should not be used in people with urinary retention. Anticholinergic agents, such as darifenacin, may also produce constipation and blurred vision. Heat prostration (due to decreased sweating) can occur when anticholinergics such as darifenacin are used in a hot environment.
Excerpted from Wikipedia’s “darifenacin” article, available under the CC BY-SA 4.0 licence.