FLNC
Sign in to saveAlso known as ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4, filamin C
protein-coding gene in the species Homo sapiens
Gene data
FLNC- Name
- filamin C
- Type
- protein-coding
- Position
- 128,830,292–128,859,275 (+)
- Aliases
- ABP-280, ABP280A, ABPA, ABPL, ARVC15, CMD1PP, CMH26, FLN2, MFM5, MPD4
- Ensembl
- ENSG00000128591
- RefSeq RNA
- NM_001127487.2, NM_001458.5
- RefSeq protein
- NP_001120959.1, NP_001449.3
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Mutations in this gene are a cause of cardiopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2022].
Gene Ontology
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
filamin C
- Symbol
- FLNC
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:128,830,292-128,859,275
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein FLNC PDB 1v05.png
Show 9 more facts
- HomoloGene ID
- 37481
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2318
- genomic end
- 128499328
- genomic start
- 128830406
- chromosome
- human chromosome 7
- cytogenetic location
- 7q32.1
- genetic association
- muscular disease
- expressed in
- triceps brachii muscle
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