flunisolide

Also known as AeroBid®, RS-3999, Flunisolide anhydrous, Flunisolida, Flunisolidum, flunisolide anhydrous

Flunisolide (marketed as AeroBid among others) is a corticosteroid often prescribed as a treatment for allergic rhinitis. Intranasal corticosteroids are the most effective medication for controlling symptoms.

Key facts

Drug.Verifiedfields: changed
Drug.verifiedrevid: 461101454
Drug.IUPAC_name: (1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Drug.image: Flunisolide.png
Drug.image_class: skin-invert-image
Drug.image2: Flunisolide ball-and-stick.png
Drug.image_class2: bg-transparent
Drug.tradename: Aerobid, Nasalide, Nasarel, others
Drug.MedlinePlus: a681048
Drug.routes_of_administration: Inhaled
Drug.protein_bound: 40% after inhalation
Drug.elimination_half life: 1.8 hours
Drug.IUPHAR_ligand: 7076
Drug.CAS_number: 3385-03-3
Drug.ATC_prefix: R01
Drug.ATC_suffix: AD04
Drug.PubChem: 82153
Drug.DrugBank: DB00180

via Wikipedia infobox

Wikidata facts

Mass: 434.21

Show 4 more facts

chemical formula: C₂₄H₃₁FO₆
canonical SMILES: CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C)F)C
isomeric SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@]35C)F)O
defined daily dose: 0.15

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Contents

Side effects
References

Flunisolide's principal mechanism of action is to activate glucocorticoid receptors, indicating an anti-inflammatory action. The effects of topical corticosteroids are not immediate and must be used for at least a few days for noticeable relief. As-needed use is less effective than regular recommended use. Flunisolide should not be used for nasal infections. It should not be continued if symptoms are not relieved after regular use for over two to three weeks.