FMO2
Sign in to saveAlso known as FMO1B1, flavin containing monooxygenase 2, flavin containing dimethylaniline monoxygenase 2
Flavin-containing monooxygenase 2 (FMO2), also known as dimethylaniline monooxygenase [N-oxide-forming] 2, is a mammalian enzyme that in humans is encoded by the FMO2 gene. The gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.
Gene data
FMO2- Name
- flavin containing dimethylaniline monoxygenase 2
- Type
- protein-coding
- Aliases
- FMO1B1
This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
via MyGene.info
Gene · Ensembl
flavin containing dimethylaniline monoxygenase 2
- Symbol
- FMO2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:171,185,249-171,212,686
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 86882
- exact match
- identifiers.org/ncbigene/2327
- genomic start
- 171185249
- genomic end
- 171212686
- cytogenetic location
- 1q24.3
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Flavin-containing monooxygenase 2 (FMO2), also known as dimethylaniline monooxygenase [N-oxide-forming] 2, is a mammalian enzyme that in humans is encoded by the FMO2 gene. The gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.
FMO2 is a member of the family of flavin-containing monooxygenases, NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. It catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate.