GLP1R
Sign in to saveAlso known as glucagon-like peptide 1 receptor, GLP-1, GLP-1-R, GLP-1R, glucagon like peptide 1 receptor
receptor activated by peptide hormone GLP-1
Gene data
GLP1R- Name
- glucagon like peptide 1 receptor
- Type
- protein-coding
- Position
- 39,048,562–39,091,303 (+)
- Aliases
- GLP-1, GLP-1-R, GLP-1R
- Ensembl
- ENSG00000112164
- RefSeq RNA
- NM_002062.5, NR_136562.2, NR_136563.2
- RefSeq protein
- NP_002053.3
This gene encodes a 7-transmembrane receptor for glucagon-like peptide 1 (GLP-1), which stimulates glucose-dependent insulin secretion. The receptor, located on the cell surface, is internalized upon ligand binding and triggers signaling pathways that regulate insulin release, appetite, gastric emptying, and energy balance. It also has neuroprotective and cardiovascular effects. Polymorphisms in this gene are linked to type 2 diabetes risk, and the receptor is a key drug target for diabetes, obesity, and stroke therapies. [provided by RefSeq, Mar 2026].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
glucagon like peptide 1 receptor
- Symbol
- GLP1R
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:39,048,562-39,091,303
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- GLP-1R apo.png
Show 8 more facts
- HomoloGene ID
- 1558
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2740
- genomic end
- 39091303
- genomic start
- 39048781
- chromosome
- human chromosome 6
- cytogenetic location
- 6p21.2
- expressed in
- pons
via Wikidata · CC0