Also known as PGR8, G protein-coupled receptor 146
G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. The receptor has been shown to bind cholesin/C7orf50, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis. Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions. GPR146 has also been identified as a possible receptor for C-peptide.
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
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G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. The receptor has been shown to bind cholesin/C7orf50, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis. Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions. GPR146 has also been identified as a possible receptor for C-peptide.
== References ==
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).