GSDMB

Also known as GSDML, PRO2521, PP4052, gasdermin B, GSDMB-1

Gasdermin B is a protein that in humans is encoded by the GSDMB gene.

Gene data

GSDMB

Name: gasdermin B
Type: protein-coding
Position: 39,904,595–39,919,854 (−)
Aliases: GSDMB-1, GSDML, PP4052, PRO2521
Ensembl: ENSG00000073605
RefSeq RNA: NM_001042471.2, NM_001165958.2, NM_001165959.2, NM_001369402.2, NM_001388420.1
RefSeq protein: NP_001035936.1, NP_001159430.1, NP_001159431.1, NP_001356331.1, NP_001375349.1

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016].