GCM2

Also known as GCMB, hGCMb, glial cells missing homolog 2, HRPT4, glial cells missing transcription factor 2, FIH2

Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.

In the Vinony graph

Vinony's link graph records 5 inbound references to GCM2, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 6.

Vinony links it to 5 Wikipedia language editions.

Gene data

GCM2

Name: GCM transcription factor 2
Type: protein-coding
Position: 10,873,223–10,882,041 (−)
Aliases: FIH2, GCMB, HRPT4, hGCMb
Ensembl: ENSG00000124827
RefSeq RNA: NM_004752.4
RefSeq protein: NP_004743.1

This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008].

Pathways

Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

glial cells missing transcription factor 2

Symbol: GCM2
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:10,873,223-10,882,041
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 3490
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9247
genomic end: 10882041
genomic start: 10873456
chromosome: human chromosome 6
cytogenetic location: 6p24.2
expressed in: body of stomach

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
Further reading

Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.

The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM]

Excerpted from Wikipedia’s “GCM2” article, available under the CC BY-SA 4.0 licence.