HTR4
Sign in to saveAlso known as 5-HT4, 5-HT4R, 5-HT4 receptor, 5-hydroxytryptamine receptor 4
protein-coding gene in the species Homo sapiens
Gene data
HTR4- Name
- 5-hydroxytryptamine receptor 4
- Type
- protein-coding
- Position
- 148,446,042–148,677,235 (−)
- Aliases
- 5-HT4, 5-HT4R
- Ensembl
- ENSG00000164270
- RefSeq RNA
- NM_000870.7, NM_001040169.2, NM_001040172.2, NM_001040173.2, NM_001040174.1
- RefSeq protein
- NP_000861.1, NP_001035259.1, NP_001035262.2, NP_001035263.1, NP_001273339.1
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010].
Gene Ontology
Biological process
system processG protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-activating G protein-coupled receptor signaling pathwayadenylate cyclase-activating serotonin receptor signaling pathway
Molecular function
G protein-coupled receptor activityG protein-coupled serotonin receptor activityG protein-coupled serotonin receptor activityG protein-coupled serotonin receptor activityG protein-coupled serotonin receptor activityG protein-coupled serotonin receptor activityprotein bindingneurotransmitter receptor activity
Pathways
Calcium signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Serotonergic synapse - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)Amine ligand-binding receptorsGPCR downstream signallingSerotonin receptors
via MyGene.info
Gene · Ensembl
5-hydroxytryptamine receptor 4
- Symbol
- HTR4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:148,446,042-148,677,235
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 20243
- exact match
- identifiers.org/ncbigene/3360
- genomic start
- 147830595
- genomic end
- 148056798
- cytogenetic location
- 5q32
- Commons category
- 5-HT4 receptor
via Wikidata · CC0
Connections
N-methylserotonin
Entity
Q180686
Entity
G protein-coupled recepteishon
Entity
Ensembl genome database project
Entity
glaucine
Entity
HTR5A
Gene
5-carboxamidotryptamine
Entity
azasetron
Entity
5-methoxytryptamine
Entity
tryptamines
Entity
α-methyl-5-HT
Entity
heart
Entity
protein
Entity
xenon
Entity
Wikidata
Entity
alcohols
Entity
ethanol
Entity
gene
Entity
chromosome
Entity
public domain
Entity