Structure via PubChem · Public domain (PubChem)
hydralazine
Sign in to saveAlso known as phthalazin-1-ylhydrazine, (1Z)-1(2H)-Phthalazinone hydrazone, APR968, hydrallazine, hydrazone 1(2H)-phthalazinone, hydralazin, 1-hydrazinophthalazine, 1-phthalazinylhydrazine
Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure. This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms. It has been found to be particularly useful in heart failure, together with isosorbide dinitrate, for treatment of people of African descent. It is given by mouth or by injection into a vein. Effects usually begin around 15 minutes and last up to six hours.
Key facts
- Drug.excretion
- Urine
- Drug.verifiedrevid
- 443859600
- Drug.image
- Hydralazine.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of hydralazine
- Drug.width
- 125
- Drug.image2
- Hydralazine-based-on-xtals-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of the hydralazine molecule
- Drug.tradename
- Apresoline, BiDil, others
- Drug.MedlinePlus
- a682246
- Drug.DailyMedID
- Hydralazine
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth, intravenous
- Drug.ATC_prefix
- C02
- Drug.ATC_suffix
- DB02
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C8H8N4
- Molecular weight
- 160.18 g/mol
- IUPAC name
- phthalazin-1-ylhydrazine
- SMILES
- C1=CC=C2C(=C1)C=NN=C2NN
- InChIKey
- RPTUSVTUFVMDQK-UHFFFAOYSA-N
- XLogP
- 0.7
- Polar surface area
- 63.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1953
- Admin. routes
- oral, parenteral
- Indications
- congestive heart failure, hypertension, neoplasm, preeclampsia
via ChEMBL · EBI
Research
6,763 papers- Genotype-Guided Hydralazine Therapy.American journal of nephrology · 2020
- A review on the clinical pharmacokinetics of hydralazine.Expert opinion on drug metabolism & toxicology · 2022
- Metabolism of hydralazine.Drug metabolism reviews · 1977
- Hydralazine and Hydrazine Derivatives: Properties, Applications, and Repositioning Potential.Chemistry & biodiversity · 2025
- Hydralazine-induced lupus.Southern medical journal · 2006
via PubMed
Wikidata facts
- Subclass of
- alkaloid
- Mass
- 160.075
- Has use
- medication
Show 9 more facts
- different from
- hydrazine
- chemical formula
- C₈H₈N₄
- medical condition treated
- arterial hypertension
- canonical SMILES
- C1=CC=C2C(=C1)C=NN=C2NN
- World Health Organisation international non-proprietary name
- hydralazine
- Commons category
- Hydralazine
- defined daily dose
- 0.1
- subject has role
- essential medicine
- stylized name
- hydrALAZINE
Sources (10)
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Medical use
- Adverse effects
- Interactions
- Mechanism of action
- Chemistry
- History
- Research
- References
Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure. This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms. It has been found to be particularly useful in heart failure, together with isosorbide dinitrate, for treatment of people of African descent. It is given by mouth or by injection into a vein. Effects usually begin around 15 minutes and last up to six hours.
Common side effects include headache and fast heart rate. It is not recommended in people with coronary artery disease or in those with rheumatic heart disease that affects the mitral valve. In those with kidney disease a low dose is recommended. Hydralazine is in the vasodilator family of medications, so it is believed to work by causing the dilation of blood vessels.
Excerpted from Wikipedia’s “hydralazine” article, available under the CC BY-SA 4.0 licence.