IFNGR2
Sign in to saveAlso known as AF-1, IFGR2, IFNGT1, IMD28, interferon gamma receptor 2 (interferon gamma transducer 1), interferon gamma receptor 2
protein-coding gene in the species Homo sapiens
Gene data
IFNGR2- Name
- interferon gamma receptor 2
- Type
- protein-coding
- Position
- 33,403,205–33,479,348 (+)
- Aliases
- AF-1, IFGR2, IFNGT1, IMD28
- Ensembl
- ENSG00000159128
- RefSeq RNA
- NM_001329128.2, NM_005534.4
- RefSeq protein
- NP_001316057.1, NP_005525.2
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
Cytokine-cytokine receptor interaction - Homo sapiens (human)HIF-1 signaling pathway - Homo sapiens (human)Necroptosis - Homo sapiens (human)Osteoclast differentiation - Homo sapiens (human)JAK-STAT signaling pathway - Homo sapiens (human)Natural killer cell mediated cytotoxicity - Homo sapiens (human)Th1 and Th2 cell differentiation - Homo sapiens (human)Th17 cell differentiation - Homo sapiens (human)Leishmaniasis - Homo sapiens (human)Chagas disease - Homo sapiens (human)
via MyGene.info