iodoquinol

Also known as Diiodohydroxyquin, Ioquin, Diiodohydroxyquinoline

The quinoline derivative diiodohydroxyquinoline (INN), or iodoquinol (USAN), brand name Diodoquin, can be used in the treatment of amoebiasis.

Chemical data

Formula: C9H5I2NO
Molecular weight: 396.95 g/mol
IUPAC name: 5,7-diiodoquinolin-8-ol
SMILES: C1=CC2=C(C(=C(C=C2I)I)O)N=C1
InChIKey: UXZFQZANDVDGMM-UHFFFAOYSA-N
XLogP: 3.1
Polar surface area: 33.1 Å²
H-bond donors: 1
H-bond acceptors: 2
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Research

322 papers

Transforming iodoquinol into broad spectrum anti-tumor leads: Repurposing to modulate redox homeostasis.Bioorganic chemistry · 2021
Iodoquinol associated seizures and radiopacity.Journal of toxicology. Clinical toxicology · 1993
Balantioides coli.Research in veterinary science · 2021
American Academy of Pediatrics Committee on Drugs: Clioquinol (iodochlorhydroxyquin, vioform) and iodoquinol (diiodohydroxyquin): blindness and neuropathy.Pediatrics · 1990
Amoebic dysentery.BMJ clinical evidence · 2011

via PubMed

Wikidata facts

Mass: 396.84606
Has use: Amebicide

Show 5 more facts

defined daily dose: 0.2
chemical formula: C₉H₅I₂NO
canonical SMILES: C1=CC2=C(C(=C(C=C2I)I)O)N=C1
medical condition treated: cystinuria
Commons category: Diiodohydroxyquinoline

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

See also
References

The quinoline derivative diiodohydroxyquinoline (INN), or iodoquinol (USAN), brand name Diodoquin, can be used in the treatment of amoebiasis.

It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It acts by chelation of ferrous ions essential for metabolism.

Excerpted from Wikipedia’s “iodoquinol” article, available under the CC BY-SA 4.0 licence.

Available in 9 languages

via Wikidata sitelinks · CC0