KIF1C

Also known as LTXS1, SATX2, SAX2, SPAX2, SPG58, kinesin family member 1C

Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene. Kif1C is a fast, plus-end directed microtubule motor. It takes processive 8nm steps along microtubules and can generate forces of up to 5 pN. Kif1C transports α5β1-integrins in human cells. Kif1C has been shown to be non-essential in mouse with other proteins able to perform the same function. However, mutations in KIF1C lead to spastic paraplegia and cerebellar dysfunction in humans. These mutations usually result in a total loss of the protein or (partial) loss of function, such as significant lower force ou

In the Vinony graph

Within Vinony's link graph, KIF1C is referenced by 7 other articles, and connects out to hair keratin, PubMed and human chromosome 17.

It is catalogued under topics including Genes on human chromosome 17, Human proteins and Motor proteins.

Its subject is documented across 5 Wikipedia language editions.

Gene data

KIF1C

Name: kinesin family member 1C
Type: protein-coding
Position: 4,997,629–5,028,401 (+)
Aliases: LTXS1, SATX2, SAX2, SPAX2, SPG58
Ensembl: ENSG00000129250
RefSeq RNA: NM_006612.6, XM_005256424.3, XM_054314745.1
RefSeq protein: NP_006603.2, XP_005256481.1, XP_054170720.1

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014].