Structure via PubChem · Public domain (PubChem)
leukotriene a4
Sign in to saveAlso known as Oxiranebutanoic acid, 3-(1,3,5,8-tetradecatetraenyl)-, (2S-(2alpha,3beta(1E,3Z,5Z,8Z)))-, 5S,6S-epoxy-7E,9E,11Z,14Z-eicosatetraenoic acid, 5(S)-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid, 5S,6S-leukotriene A4, (5S,6S,7E,9E,11Z,14Z)-5,6-Epoxyicosa-7,9,11,14-tetraenoate
chemical compound
In the Vinony graph
Vinony's link graph records 103 inbound references to leukotriene a4, and connects out to arachidonate 5-lipoxygenase, 5S-HPETE and LTA4H.
It is catalogued under the topic Eicosanoids.
Vinony links it to 9 Wikipedia language editions.
Chemical data
- Formula
- C20H30O3
- Molecular weight
- 318.4 g/mol
- IUPAC name
- 4-[(2S,3S)-3-[(1E,3E,5Z,8Z)-tetradeca-1,3,5,8-tetraenyl]oxiran-2-yl]butanoic acid
- SMILES
- CCCCC/C=C\C/C=C\C=C\C=C\[C@H]1[C@@H](O1)CCCC(=O)O
- InChIKey
- UFPQIRYSPUYQHK-WAQVJNLQSA-N
- XLogP
- 5.3
- Polar surface area
- 49.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1,363 papers- Leukotriene A4 hydrolase.Prostaglandins & other lipid mediators · 2002
- Leukotriene A4 hydrolase: an emerging target of natural products for cancer chemoprevention and chemotherapy.Annals of the New York Academy of Sciences · 2018
- Leukotriene A4 signaling, inflammation, and cancer.Journal of the National Cancer Institute · 2003
- Leukotriene A4 hydrolase as a target for cancer prevention and therapy.Current cancer drug targets · 2004
- Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function.Science advances · 2023
via PubMed
Wikidata facts
- Subclass of
- leukotriene
- Has part
- carbon
- Mass
- 318.219495
Show 5 more facts
- subject has role
- primary metabolite
- found in taxon
- Homo sapiens
- chemical formula
- C₂₀H₃₀O₃
- canonical SMILES
- CCCCCC=CCC=CC=CC=CC1C(O1)CCCC(=O)O
- isomeric SMILES
- CCCCC/C=C\C/C=C\C=C\C=C\[C@H]1[C@@H](O1)CCCC(=O)O
via Wikidata · CC0
Connections
arachidonate 5-lipoxygenase
Entity
5S-HPETE
Entity
LTA4H
Gene
ALOX5AP
Gene
enzyme
Entity
fever
Entity
childbirth
Entity
digital object identifier
Entity
chemical formula
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International Standard Serial Number
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bibcode
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