Structure via PubChem · Public domain (PubChem)
azelastine
Sign in to saveAlso known as A-5610, Astelin®, E-0659, Rhinolast®, W-2979M, 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone, 4-(P-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone
Azelastine, sold under the brand name Astelin among others, is a H1 receptor-blocking medication primarily used as a nasal spray to treat allergic rhinitis (hay fever) and as eye drops for allergic conjunctivitis. Other uses may include asthma and skin rashes for which it is taken by mouth. Onset of effects is within minutes when used in the eyes and within an hour when used in the nose. Effects last for up to 12 hours.
Key facts
- Drug.verifiedrevid
- 458613328
- Drug.image
- Azelastine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 150
- Drug.image2
- Azelastine-based-on-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200
- Drug.tradename
- Astelin, others
- Drug.MedlinePlus
- a603009
- Drug.DailyMedID
- Azelastine
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- Eye drops, nasal spray, by mouth
- Drug.ATC_prefix
- R01
- Drug.ATC_suffix
- AC03
- Drug.ATC_supplemental
- ,
- Drug.legal_AU
- S4
- Drug.legal_AU_comment
- /Schedule 2
- Drug.legal_UK
- POM
via Wikipedia infobox
Chemical data
- Formula
- C22H24ClN3O
- Molecular weight
- 381.9 g/mol
- IUPAC name
- 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
- SMILES
- CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl
- InChIKey
- MBUVEWMHONZEQD-UHFFFAOYSA-N
- XLogP
- 4.4
- Polar surface area
- 35.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
870 papers- Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections: A Phase 2 Randomized Clinical Trial.JAMA internal medicine · 2025
- Antiviral Potential of Azelastine against Major Respiratory Viruses.Viruses · 2023
- Azelastine Nasal Spray in Non-Hospitalized Subjects with Mild COVID-19 Infection: A Randomized Placebo-Controlled, Parallel-Group, Multicentric, Phase II Clinical Trial.Viruses · 2024
- Azelastine/fluticasone propionate(Dymista) for seasonal allergic rhinitis.The Medical letter on drugs and therapeutics · 2012
- Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients.Scientific reports · 2023
via PubMed
Wikidata facts
- Mass
- 381.16079
Show 5 more facts
- chemical formula
- C₂₂H₂₄ClN₃O
- canonical SMILES
- CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl
- World Health Organisation international non-proprietary name
- azelastine
- defined daily dose
- 4
- Commons category
- Azelastine
via Wikidata · CC0
~5 min read
Article
10 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Metabolism
- Chemical properties
- History
- Research
- References
Azelastine, sold under the brand name Astelin among others, is a H1 receptor-blocking medication primarily used as a nasal spray to treat allergic rhinitis (hay fever) and as eye drops for allergic conjunctivitis. Other uses may include asthma and skin rashes for which it is taken by mouth. Onset of effects is within minutes when used in the eyes and within an hour when used in the nose. Effects last for up to 12 hours.
Common side effects include headache, sleepiness, change in taste, and sore throat. It is unclear if use is safe during pregnancy or breastfeeding. It is a second-generation antihistamine and works by blocking the release of a number of inflammatory mediators including histamine.