Structure via PubChem · Public domain (PubChem)
licarbazepine
Sign in to saveAlso known as TRI477, GP 47779, 10-hydroxycarbamazepine, 10,11-dihydro-10-hydroxycarbamazepine
Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an enantiomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.
Chemical data
- Formula
- C15H14N2O2
- Molecular weight
- 254.28 g/mol
- IUPAC name
- 5-hydroxy-5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide
- SMILES
- C1C(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)N)O
- InChIKey
- BMPDWHIDQYTSHX-UHFFFAOYSA-N
- XLogP
- 1.4
- Polar surface area
- 66.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- epilepsy, bipolar I disorder, bipolar disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 254.106
Show 4 more facts
- chemical formula
- C₁₅H₁₄N₂O₂
- canonical SMILES
- C1C(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)N)O
- World Health Organisation international non-proprietary name
- licarbazepine
- Commons category
- Licarbazepine
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an enantiomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.
== References ==
Excerpted from Wikipedia’s “licarbazepine” article, available under the CC BY-SA 4.0 licence.