LSM4

Also known as GRP, YER112W, LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to LSM4, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 19.

Vinony links it to 6 Wikipedia language editions.

Gene data

LSM4

Name: LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
Type: protein-coding
Position: 18,306,231–18,323,112 (−)
Aliases: GRP, YER112W
Ensembl: ENSG00000130520
RefSeq RNA: NM_001252129.2, NM_012321.5
RefSeq protein: NP_001239058.1, NP_036453.1

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

Pathways

RNA degradation - Homo sapiens (human)Spliceosome - Homo sapiens (human)Deadenylation-dependent mRNA decay Deadenylation-dependent mRNA decay mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA Metabolism of RNA

via MyGene.info

Gene · Ensembl

LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated

Symbol: LSM4
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:18,306,231-18,323,112
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 134555
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/25804
genomic end: 18323112
genomic start: 18306236
chromosome: human chromosome 19
cytogenetic location: 19p13.11

Sources (3)

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Encyclopedic overview

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Contents

References
Further reading

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]

Excerpted from Wikipedia’s “LSM4” article, available under the CC BY-SA 4.0 licence.