MAF1
Sign in to saveAlso known as MAF1 homolog, negative regulator of RNA polymerase III
Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.
Gene data
MAF1- Name
- MAF1 negative regulator of RNA polymerase III
- Type
- protein-coding
This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
MAF1 negative regulator of RNA polymerase III
- Symbol
- MAF1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:144,103,112-144,107,618
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Cyrstal Structure of Repressor of RNA polymerase III transcription MAF1.png
Show 5 more facts
- HomoloGene ID
- 49867
- exact match
- identifiers.org/ncbigene/84232
- genomic end
- 145162514
- genomic start
- 144104461
- cytogenetic location
- 8q24.3
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.
This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses Pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.