NFX1
Sign in to saveAlso known as NFX2, TEG-42, Tex42, nuclear transcription factor, X-box binding 1
Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.
In the Vinony graph
Vinony's link graph records 3 inbound references to NFX1, and connects out to PubMed, human chromosome 9 and homeobox.
It sits within the topics Genes on human chromosome 9 and Transcription factors.
Vinony links it to 5 Wikipedia language editions.
Gene data
NFX1- Name
- nuclear transcription factor, X-box binding 1
- Type
- protein-coding
- Position
- 33,290,428–33,372,467 (+)
- Aliases
- NFX2, TEG-42, Tex42
- Ensembl
- ENSG00000086102
- RefSeq RNA
- NM_001318758.2, NM_002504.6, NM_147133.2, NM_147134.4, XM_047423427.1
- RefSeq protein
- NP_001305687.1, NP_002495.2, NP_667345.1, XP_047279383.1, XP_047279384.1
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
nuclear transcription factor, X-box binding 1
- Symbol
- NFX1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:33,290,428-33,372,467
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 1875
- genomic end
- 33371157
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4799
- genomic start
- 33290512
- chromosome
- human chromosome 9
- cytogenetic location
- 9p13.3
- expressed in
- biceps brachii
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.
Excerpted from Wikipedia’s “NFX1” article, available under the CC BY-SA 4.0 licence.