NXT1

Also known as MTR2, P15, nuclear transport factor 2 like export factor 1

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

In the Vinony graph

Within Vinony's link graph, NXT1 is referenced by 4 other articles, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 20.

Its subject is documented across 5 Wikipedia language editions.

Gene data

NXT1

Name: nuclear transport factor 2 like export factor 1
Type: protein-coding
Position: 23,350,148–23,354,771 (+)
Aliases: MTR2, P15
Ensembl: ENSG00000132661
RefSeq RNA: NM_013248.3
RefSeq protein: NP_037380.1

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

mRNA export from nucleus nucleocytoplasmic transport poly(A)+ mRNA export from nucleus

Molecular function

protein binding small GTPase binding

Cellular component

nucleus nucleus nuclear pore nuclear pore nucleoplasm nucleoplasm cytoplasm cytoplasm

Pathways

Ribosome biogenesis in eukaryotes - Homo sapiens (human)RNA transport - Homo sapiens (human)mRNA surveillance pathway - Homo sapiens (human)Amyotrophic lateral sclerosis - Homo sapiens (human)Influenza A - Homo sapiens (human)Transport of Mature mRNA derived from an Intron-Containing Transcript Transport of Mature Transcript to Cytoplasm Processing of Capped Intron-Containing Pre-mRNA Metabolism of RNA

via MyGene.info

Gene · Ensembl

nuclear transport factor 2 like export factor 1

Symbol: NXT1
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:23,350,148-23,354,771
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein NXT1 PDB 1jkg.png

Show 7 more facts

HomoloGene ID: 8301
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/29107
genomic end: 23354771
genomic start: 23350791
chromosome: human chromosome 20
cytogenetic location: 20p11.21

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.

Excerpted from Wikipedia’s “NXT1” article, available under the CC BY-SA 4.0 licence.