NDEL1
Sign in to saveAlso known as EOPA, MITAP1, NDE1L1, NDE2, NUDEL, nudE neurodevelopment protein 1 like 1
Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.
In the Vinony graph
Vinony's link graph records 10 inbound references to NDEL1, and connects out to PubMed, cell cycle and Ensembl genome database project.
It is catalogued under topics including Genes on human chromosome 17 and Human proteins.
Vinony links it to 6 Wikipedia language editions.
Gene data
NDEL1- Name
- nudE neurodevelopment protein 1 like 1
- Type
- protein-coding
- Position
- 8,408,528–8,501,107 (+)
- Aliases
- EOPA, MITAP1, NDE1L1, NDE2, NUDEL
- Ensembl
- ENSG00000166579
- RefSeq RNA
- NM_001025579.3, NM_001330129.2, NM_030808.5, XM_017025183.2, XM_017025184.2
- RefSeq protein
- NP_001020750.1, NP_001317058.1, NP_110435.1, XP_016880672.1, XP_016880673.1
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
nudE neurodevelopment protein 1 like 1
- Symbol
- NDEL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:8,408,528-8,501,107
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 32567
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/81565
- genomic end
- 8393729
- genomic start
- 8316449
- chromosome
- human chromosome 17
- cytogenetic location
- 17p13.1
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Other Interactions
- References
- Further reading
Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.
It plays a significant role in intracellular transport and the process of cellular division via regulation of the dynein motor protein and its cofactor protein, Lis1. Ndel1 is a highly conserved protein and its human gene, NDEL1 is expressed in a wide variety of brain tissues which contributes to neuronal function and development. Nde1 and Ndel1 were in the past referred to as NudE and NudEL respectively. The Nde1 protein is involved in nuclear migration throughout the process of neurogenesis. Studies have revealed that Ndel1 is structurally similar to Nde1 which both play a role in microtubule-based transport. Ndel1 and Nde1 are also thought to be associated with neurodevelopmental and psychiatric disorders. Secondary structure of Ndel1 is composed of various distinct domains: a C-terminal region, and a 200 amino acid N-terminal coiled-coil domain. The coiled-coil domain of Ndel1 serves as a self-associating stable parallel homodimer. Such structural components help with interactions between an array of binding partners, including the motor protein dynein and its cofactor protein, Lis1. Ndel1 forms a heterotetramer complex with Lis1 via the N-terminal coiled-coil domain. The Ndel1 N-terminal coiled-coil domain mediates binding to dynein, whereas the C-terminal domain interacts with Lis1, regulating the activity of the dynein complex.
Excerpted from Wikipedia’s “NDEL1” article, available under the CC BY-SA 4.0 licence.