RAE1
Sign in to saveAlso known as MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1, ribonucleic acid export 1, Gle2
mRNA export factor is a protein that in humans is encoded by the RAE1 gene.
In the Vinony graph
Vinony's link graph records 8 inbound references to RAE1, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 20.
Vinony links it to 5 Wikipedia language editions.
Gene data
RAE1- Name
- ribonucleic acid export 1
- Type
- protein-coding
- Position
- 57,351,218–57,380,114 (+)
- Aliases
- Gle2, MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1
- Ensembl
- ENSG00000101146
- RefSeq RNA
- NM_001015885.2, NM_003610.4, XM_005260582.3, XM_005260583.3, XM_011529087.3
- RefSeq protein
- NP_001015885.1, NP_003601.1, XP_005260639.2, XP_005260640.2, XP_011527389.1
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
ribonucleic acid export 1
- Symbol
- RAE1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:57,351,218-57,380,114
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- exact match
- identifiers.org/ncbigene/8480
- HomoloGene ID
- 2676
- found in taxon
- Homo sapiens
- genomic end
- 55954267
- genomic start
- 57351223
- chromosome
- human chromosome 20
- cytogenetic location
- 20q13.31
- expressed in
- bone marrow
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
mRNA export factor is a protein that in humans is encoded by the RAE1 gene.
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Excerpted from Wikipedia’s “RAE1” article, available under the CC BY-SA 4.0 licence.