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GeneQ18028621· pop 5· linked from 812 articles

LMX1A

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Also known as LMX1, LMX1.1, LIM homeobox transcription factor 1 alpha, DFNA7

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.

In the Vinony graph

Vinony's link graph records 812 inbound references to LMX1A, and connects out to Q180686, human chromosome 1 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 1.

Vinony links it to 5 Wikipedia language editions.

Gene data

LMX1A

Name: LIM homeobox transcription factor 1 alpha
Type: protein-coding
Position: 165,201,867–165,356,721 (−)
Aliases: DFNA7, LMX1, LMX1.1
Ensembl: ENSG00000162761
RefSeq RNA: NM_001033507.1, NM_001174069.2, NM_177398.4, NM_177399.2, XM_011509538.4
RefSeq protein: NP_001167540.1, NP_796372.1, XP_011507840.1, XP_011507842.1, XP_054192569.1

This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II neuron differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II synapse organization dopaminergic neuron differentiation dopaminergic neuron differentiation

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus

Pathways

Dopaminergic Neurogenesis

via MyGene.info

Gene · Ensembl

LIM homeobox transcription factor 1 alpha

Symbol: LMX1A
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:165,201,867-165,356,721
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 24921
exact match: identifiers.org/ncbigene/4009
genomic end: 165325952
genomic start: 165171104
cytogenetic location: 1q23.3

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.

== Function ==

Excerpted from Wikipedia’s “LMX1A” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 1