MAFG

Also known as hMAF, MAF bZIP transcription factor G

Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.

Gene data

MAFG

Name: MAF bZIP transcription factor G
Type: protein-coding
Position: 81,918,270–81,927,735 (−)
Aliases: hMAF
Ensembl: ENSG00000197063
RefSeq RNA: NM_002359.4, NM_032711.4, XM_047436068.1, XM_047436069.1, XM_047436070.1
RefSeq protein: NP_002350.1, NP_116100.2, XP_047292024.1, XP_047292025.1, XP_047292026.1

Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II

~5 min read

Article

10 sections

Contents

Discovery
Structure
Expression
Function
Target genes
Disease linkage
Notes
References
Further reading
External links

Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.

MafG is one of the small Maf proteins, which are basic region and leucine zipper (bZIP)-type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFG is “v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G”.