MAP3K5

Name

mitogen-activated protein kinase kinase kinase 5

Type

protein-coding

Position

136,557,030–136,793,103 (−)

Aliases

ASK1, MAPKKK5, MEKK5

Ensembl

ENSG00000197442

RefSeq RNA

NM_001438058.1, NM_001438579.1, NM_005923.4, XM_011535839.4, XM_017010872.2

RefSeq protein

NP_001424987.1, NP_001425508.1, NP_005914.1, XP_011534141.2, XP_016866361.1

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

mitogen-activated protein kinase kinase kinase 5

Symbol

MAP3K5

Biotype

Protein coding

Organism

Homo sapiens

Location

6:136,557,030-136,793,103

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein MAP3K5 PDB 2clq.png

via Wikidata · CC0