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mepiprazole
Sign in to saveMepiprazole (INN, BAN; brand name Psigodal) is an anxiolytic drug of the phenylpiperazine group with additional antidepressant properties that is marketed in Spain. It acts as a 5-HT2A and α1-adrenergic receptor antagonist and inhibits the reuptake and induces the release of serotonin, dopamine, and norepinephrine to varying extents, and has been described as a serotonin antagonist and reuptake inhibitor (SARI).
Chemical data
- Formula
- C16H21ClN4
- Molecular weight
- 304.82 g/mol
- IUPAC name
- 1-(3-chlorophenyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethyl]piperazine
- SMILES
- CC1=CC(=NN1)CCN2CCN(CC2)C3=CC(=CC=C3)Cl
- InChIKey
- DOTIMEKVTCOGED-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 35.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 304.145
- Has use
- medication
Show 3 more facts
- chemical formula
- C₁₆H₂₁ClN₄
- canonical SMILES
- CC1=CC(=NN1)CCN2CCN(CC2)C3=CC(=CC=C3)Cl
- Commons category
- Mepiprazole
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Uses
- See also
- References
Mepiprazole (INN, BAN; brand name Psigodal) is an anxiolytic drug of the phenylpiperazine group with additional antidepressant properties that is marketed in Spain. It acts as a 5-HT2A and α1-adrenergic receptor antagonist and inhibits the reuptake and induces the release of serotonin, dopamine, and norepinephrine to varying extents, and has been described as a serotonin antagonist and reuptake inhibitor (SARI).
== Uses == Controlled clinical trials of mepiprazole in patients with irritable bowel syndrome (IBS) were also carried out and suggested some benefits of the drug in relieving symptoms of IBS in some patients. Similarly to other phenylpiperazines like trazodone, nefazodone, and etoperidone, mepiprazole produces mCPP as an active metabolite.
Excerpted from Wikipedia’s “mepiprazole” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0