متیل‌دوپا

Also known as Aldomet®, Aldoril®, Dopamet®, L-α-Methyl-3,4-dihydroxyphenylalanine, alpha-Methyldopa, alpha-Methyl dopa, alpha-Methyl-beta-(3,4-dihydroxyphenyl)-L-alanine, (S)-(-)-alpha-Methyldopa

Methyldopa, also known as α-methyl-L-DOPA and sold under the brand name Aldomet among others, is a medication used for high blood pressure. It is one of the preferred treatments for high blood pressure in pregnancy. For other types of high blood pressure including very high blood pressure resulting in symptoms other medications are typically preferred. It can be given by mouth or injection into a vein. Onset of effects is around 5 hours and they last about a day.

Chemical data

Formula: C10H13NO4
Molecular weight: 211.21 g/mol
IUPAC name: (2S)-2-azaniumyl-3-(3,4-dihydroxyphenyl)-2-methylpropanoate
SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)[O-])[NH3+]
InChIKey: CJCSPKMFHVPWAR-JTQLQIEISA-N
XLogP: -2.8
Polar surface area: 108 Å²
H-bond donors: 3
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1962
Admin. routes: oral
Indications: preeclampsia, hypertension, type 1 diabetes mellitus

via ChEMBL · EBI

Research

7,501 papers

Methyldopa as an inductor of postpartum depression and maternal blues: A review.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
Methyldopa.British journal of clinical pharmacology · 1982
ALPHA-METHYLDOPA IN THE TREATMENT OF HYPERTENSION.The Medical clinics of North America · 1964
Methyldopa fever.Archives of internal medicine · 1968
Methyldopa poisoning.Journal of toxicology. Clinical toxicology · 1982

via PubMed

Wikidata facts

Mass: 211.084458
Has use: medication

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chemical formula: C₁₀H₁₃NO₄
route of administration: oral administration
World Health Organisation international non-proprietary name: methyldopa
medical condition treated: arterial hypertension
canonical SMILES: CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)N
isomeric SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N
Commons category: Methyldopa
subject has role: essential medicine
MCN code: 3003.90.45
significant drug interaction: entacapone

Sources (5)

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via Wikidata sitelinks · CC0