MICU1

Also known as CALC, CBARA1, EFHA3, MPXPS, mitochondrial calcium uptake 1, ara CALC

Calcium-binding atopy-related autoantigen 1 is a protein that in humans is encoded by the CBARA1 gene.

In the Vinony graph

Within Vinony's link graph, MICU1 is referenced by 8 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

It sits within the topics EF-hand-containing proteins and Genes on human chromosome 10.

Its subject is documented across 5 Wikipedia language editions.

Gene data

MICU1

Name: mitochondrial calcium uptake 1
Type: protein-coding
Position: 72,355,297–72,626,134 (−)
Aliases: CALC, CBARA1, EFHA3, MPXPS, ara CALC
Ensembl: ENSG00000107745
RefSeq RNA: NM_001195518.2, NM_001195519.2, NM_001363513.2, NM_001441218.1, NM_001441219.1
RefSeq protein: NP_001182447.1, NP_001182448.1, NP_001350442.1, NP_001428147.1, NP_001428148.1

This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013].