Structure via PubChem · Public domain (PubChem)
mofebutazone
Sign in to saveAlso known as 1-Phenyl-4-butyl-3,5-pyrazolidinedione, Mophebutazone, Monophenylbutazone, 4-Butyl-1-phenyl-3,5-dioxopyrazolidine, 4-Butyl-1-phenyl-3,5-pyrazolidinedione, 2 Fdbp, 2-Phenyl-3,5-dihydroxy-4-butylpyrazolidine
Mofebutazone (or monophenylbutazone) is a drug used for joint and muscular pain. It is a 3,5-pyrazolinedione derivative.
Chemical data
- Formula
- C13H16N2O2
- Molecular weight
- 232.28 g/mol
- IUPAC name
- 4-butyl-1-phenylpyrazolidine-3,5-dione
- SMILES
- CCCCC1C(=O)NN(C1=O)C2=CC=CC=C2
- InChIKey
- REOJLIXKJWXUGB-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 49.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Arthralgia, rheumatic disease, Myalgia
via ChEMBL · EBI
Research
30 papers- Structure of phenylbutazone and mofebutazone in the crystalline state and in solution.Journal of pharmaceutical sciences · 1987
- Pharmacokinetics of [4-14C] mofebutazone after oral administration in man.European journal of drug metabolism and pharmacokinetics · 1984
- [Mofebutazone--evaluation of possible interaction with glibenclamide].Fortschritte der Medizin · 1993
- Influence of phenylbutazone, mofebutazone and aspirin on the pharmacokinetics of dexamethasone in the rat.European journal of drug metabolism and pharmacokinetics · 1981
- [Distribution of 4-14C-mofebutazone in the rat].Zeitschrift fur Rheumatologie · 1986
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 232.121
Show 4 more facts
- canonical SMILES
- CCCCC1C(=O)NN(C1=O)C2=CC=CC=C2
- World Health Organisation international non-proprietary name
- mofebutazone
- chemical formula
- C₁₃H₁₆N₂O₂
- subject has role
- non-steroidal anti-inflammatory drug
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Mofebutazone (or monophenylbutazone) is a drug used for joint and muscular pain. It is a 3,5-pyrazolinedione derivative.
The drug binds to plasma albumin and competes with drugs such as coumarin anticoagulants, indomethacin and glucocorticoids.
Excerpted from Wikipedia’s “mofebutazone” article, available under the CC BY-SA 4.0 licence.