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mt-45
Sign in to saveMT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl) piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main op
In the Vinony graph
Within Vinony's link graph, mt-45 is referenced by 1,262 other articles, and connects out to (+)-catechin, butorphanol and 1-phenylpiperazine.
It is catalogued under topics including 1,2-Diarylethylamines, Chemical pages without DrugBank identifier and Cyclohexylamines.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C24H32N2
- Molecular weight
- 348.5 g/mol
- IUPAC name
- 1-cyclohexyl-4-(1,2-diphenylethyl)piperazine
- SMILES
- C1CCC(CC1)N2CCN(CC2)C(CC3=CC=CC=C3)C4=CC=CC=C4
- InChIKey
- IGBRRSIHEGCUEN-UHFFFAOYSA-N
- XLogP
- 5.4
- Polar surface area
- 6.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 348.257
Show 2 more facts
- chemical formula
- C₂₄H₃₂N₂
- canonical SMILES
- C1CCC(CC1)N2CCN(CC2)C(CC3=CC=CC=C3)C4=CC=CC=C4
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Side effects
- Legality
- See also
- References
MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl) piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes. Fluorinated derivatives of MT-45 such as 2F-MT-45 are significantly more potent as μ-opioid receptor agonists, and one of its main metabolites 1,2-diphenylethylpiperazine also blocks NMDA receptors.
180px|thumb|left|class=skin-invert-image|2F-MT-45.
Excerpted from Wikipedia’s “mt-45” article, available under the CC BY-SA 4.0 licence.