MT-RNR1
Sign in to savethumb|Location of the MT-RNR1 gene on the H strand of the human mitochondrial genome. MT-RNR1, or RRNS, is one of the two mitochondrial ribosomal RNA genes (blue boxes).
Gene · Ensembl
mitochondrially encoded 12S rRNA
- Symbol
- MT-RNR1
- Biotype
- Mt rRNA
- Organism
- Homo sapiens
- Location
- Chr MT:648-1,601
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~3 min read
Article
7 sectionsContents
- Structure
- Function
- Clinical significance
- Nonsyndromic hearing loss and deafness, mitochondrial
- Complex IV Deficiency
- References
- External links
thumb|Location of the MT-RNR1 gene on the H strand of the human mitochondrial genome. MT-RNR1, or RRNS, is one of the two mitochondrial ribosomal RNA genes (blue boxes).
Mitochondrially encoded 12S ribosomal RNA (often abbreviated as 12S or 12S rRNA) is the SSU rRNA of the mitochondrial ribosome. In humans, 12S is encoded by the MT-RNR1 gene and is 959 nucleotides long. MT-RNR1 is one of the 37 genes contained in animal mitochondria genomes. Their 2 rRNA, 22 tRNA and 13 mRNA genes are very useful in phylogenetic studies, in particular the 12S and 16S rRNAs. The 12S rRNA is the mitochondrial homologue of the prokaryotic 16S and eukaryotic nuclear 18S ribosomal RNAs. Mutations in the MT-RNR1 gene may be associated with hearing loss. The rRNA gene also encodes a peptide MOTS-c, also known as Mitochondrial-derived peptide MOTS-c or Mitochondrial open reading frame of the 12S rRNA-c.