NAA80
Sign in to saveAlso known as FUS-2, FUS2, N-acetyltransferase 6, NAT6, N(alpha)-acetyltransferase 80, NatH catalytic subunit, HsNAAA80, N-alpha-acetyltransferase 80, NatH catalytic subunit
thumb|alt=|320x320px|Crystal structure of [[Drosophila melanogaster Naa80. Substrate peptide is shown as yellow sticks and CoA is shown as cyan sticks. Enzyme is displayed as cyan cartoon. (PDB ID: 5WJE)]]N-acetyltransferase 80 (also known as NAT6 or FUS2) is a protein that in humans is encoded by the NAA80 gene. It acetylates the N-terminus of mature actin.
In the Vinony graph
Within Vinony's link graph, NAA80 is referenced by 2 other articles, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 3.
Its subject is documented across 5 Wikipedia language editions.
Gene data
NAA80- Name
- N-alpha-acetyltransferase 80, NatH catalytic subunit
- Type
- protein-coding
- Position
- 50,296,402–50,299,437 (−)
- Aliases
- ANDS, FUS-2, FUS2, HsNAAA80, NAT6
- Ensembl
- ENSG00000243477
- RefSeq RNA
- NM_001200016.2, NM_001200018.2, NM_012191.4
- RefSeq protein
- NP_001186945.1, NP_001186947.1, NP_036323.2
This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
N-alpha-acetyltransferase 80, NatH catalytic subunit
- Symbol
- NAA80
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:50,296,402-50,299,437
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 36325
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/24142
- chromosome
- human chromosome 3
- genomic start
- 50333833
- genomic end
- 50299416
- cytogenetic location
- 3p21.31
- expressed in
- prefrontal cortex
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Structure
- Clinical Significance
- References
- Further reading
thumb|alt=|320x320px|Crystal structure of [[Drosophila melanogaster Naa80. Substrate peptide is shown as yellow sticks and CoA is shown as cyan sticks. Enzyme is displayed as cyan cartoon. (PDB ID: 5WJE)]]N-acetyltransferase 80 (also known as NAT6 or FUS2) is a protein that in humans is encoded by the NAA80 gene. It acetylates the N-terminus of mature actin.
== Function ==
Excerpted from Wikipedia’s “NAA80” article, available under the CC BY-SA 4.0 licence.