NEIL1

Also known as FPG1, NEI1, hFPG1, nei like DNA glycosylase 1

Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.

Gene data

NEIL1

Name: nei like DNA glycosylase 1
Type: protein-coding
Aliases: FPG1, NEI1, hFPG1

This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].

via MyGene.info

Gene · Ensembl

nei like DNA glycosylase 1

Symbol: NEIL1
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:75,346,878-75,357,115
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein NEIL1 PDB 1tdh.png

Show 5 more facts

HomoloGene ID: 11616
exact match: identifiers.org/ncbigene/79661
genomic end: 75357115
genomic start: 75639296
cytogenetic location: 15q24.2

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Article

7 sections

Contents

Targets
Deficiency in cancer
Memory retention
Stroke prevention
See also
References
Further reading

Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species (ROS) and introducing a DNA strand break via the associated lyase reaction.