Structure via PubChem · Public domain (PubChem)
niclosamide
Sign in to saveAlso known as BAY-2353, Ex A Lint, Lintex, Nicloside, Niclocide, Yomesan
Niclosamide, sold under the brand name Niclocide among others, is an anthelmintic medication used to treat tapeworm infestations, including diphyllobothriasis, hymenolepiasis, and taeniasis. It is not effective against other worms such as flukes or roundworms. It is taken by mouth.
Chemical data
- Formula
- C13H8Cl2N2O4
- Molecular weight
- 327.12 g/mol
- IUPAC name
- 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
- SMILES
- C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
- InChIKey
- RJMUSRYZPJIFPJ-UHFFFAOYSA-N
- XLogP
- 4
- Polar surface area
- 95.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
1,666 papers- Niclosamide-A promising treatment for COVID-19.British journal of pharmacology · 2022
- Niclosamide: A career builder.Journal of controlled release : official journal of the Controlled Release Society · 2024
- Niclosamide as a Promising Therapeutic Player in Human Cancer and Other Diseases.International journal of molecular sciences · 2022
- Revisiting Niclosamide Formulation Approaches - a Pathway Toward Drug Repositioning.Drug design, development and therapy · 2024
- Niclosamide: Beyond an antihelminthic drug.Cellular signalling · 2018
via PubMed
Wikidata facts
- Mass
- 325.986112
Show 4 more facts
- chemical formula
- C₁₃H₈Cl₂N₂O₄
- canonical SMILES
- C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
- Commons category
- Niclosamide
- defined daily dose
- 2
via Wikidata · CC0
~3 min read
Article
7 sectionsContents
- Side effects
- Mechanism of action
- Use as a pesticide
- Medical research
- References
- Further reading
- External links
Niclosamide, sold under the brand name Niclocide among others, is an anthelmintic medication used to treat tapeworm infestations, including diphyllobothriasis, hymenolepiasis, and taeniasis. It is not effective against other worms such as flukes or roundworms. It is taken by mouth.
Side effects include nausea, vomiting, abdominal pain, and itchiness. It may be used during pregnancy. It works by blocking glucose uptake and oxidative phosphorylation by the worm.