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niludipine
Sign in to saveNiludipine is a calcium channel blocker of the dihydropyridine class. It is a vasodilator that acts upon the coronary arteries of the heart-lung. It was found to produce a calcium antagonistic effect on the smooth muscle of hearts of canines and guinea pigs inhibiting myocardial oxidative metabolism.
In the Vinony graph
Within Vinony's link graph, niludipine is referenced by 322 other articles, and connects out to valproic acid, (RS)-baclofen and voltage-gated sodium channel.
It is catalogued under topics including 3-Nitrophenyl compounds, Calcium channel blockers and Carboxylate esters.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C25H34N2O8
- Molecular weight
- 490.5 g/mol
- IUPAC name
- bis(2-propoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- SMILES
- CCCOCCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOCCC)C)C
- InChIKey
- VZWXXKDFACOXNT-UHFFFAOYSA-N
- XLogP
- 3.9
- Polar surface area
- 129 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
44 papers- Effects of Ca antagonists, nifedipine, niludipine and verapamil, on endocrine function of the pancreas.The Tohoku journal of experimental medicine · 1983
- Treatment of angina pectoris patients with niludipine a new calcium antagonistic drug.Arzneimittel-Forschung · 1981
- Antihypertensive effect of Niludipine (Bay a 7168) on conscious renal-hypertensive dogs.Arzneimittel-Forschung · 1979
- Acute hypotensive, hemodynamic effects of long-term treatment with niludipine, a Ca2+-antagonist, in patients with essential hypertension. Niludipine monotherapy and combination with a beta-blocker and a diuretic).Arzneimittel-Forschung · 1982
- Protection of the ischemic myocardium with calcium antagonistic drugs.Arzneimittel-Forschung · 1983
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 490.231516
Show 4 more facts
- canonical SMILES
- CCCOCCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOCCC)C)C
- chemical formula
- C₂₅H₃₄N₂O₈
- subject has role
- calcium channel blocker
- Commons category
- Niludipine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Niludipine is a calcium channel blocker of the dihydropyridine class. It is a vasodilator that acts upon the coronary arteries of the heart-lung. It was found to produce a calcium antagonistic effect on the smooth muscle of hearts of canines and guinea pigs inhibiting myocardial oxidative metabolism.
==References==
Excerpted from Wikipedia’s “niludipine” article, available under the CC BY-SA 4.0 licence.