nortriptyline
Also known as 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, demethylamitriptyline, desmethylamitriptyline, 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-delta(5,gamma)-propylamine, 10,11-dihydro-N-Methyl-5H-dibenzo[a,d]cycloheptene-delta(5,gamma)-propylamine, Pamelor
Nortriptyline, sold under the brand name Aventyl, among others, is a tricyclic antidepressant. This medicine is also sometimes used for neuropathic pain, attention deficit hyperactivity disorder (ADHD), smoking cessation and anxiety. Its use for young people with depression and other psychiatric disorders may be limited due to increased suicidality in the 18–24 population initiating treatment. Nortriptyline is not a preferred treatment for attention deficit hyperactivity disorder or smoking cessation. It is taken by mouth.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462263374
- Drug.image
- Nortriptyline.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of nortriptyline
- Drug.width
- 200
- Drug.image2
- Nortriptyline-from-4M48-ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of the nortriptyline molecule
- Drug.width2
- 200
- Drug.tradename
- Aventyl, others
- Drug.MedlinePlus
- a682620
- Drug.DailyMedID
Article
15 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacogenetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Research
- References
Nortriptyline, sold under the brand name Aventyl, among others, is a tricyclic antidepressant. This medicine is also sometimes used for neuropathic pain, attention deficit hyperactivity disorder (ADHD), smoking cessation and anxiety. Its use for young people with depression and other psychiatric disorders may be limited due to increased suicidality in the 18–24 population initiating treatment. Nortriptyline is not a preferred treatment for attention deficit hyperactivity disorder or smoking cessation. It is taken by mouth.
Common side effects include dry mouth, constipation, blurry vision, sleepiness, low blood pressure with standing, and weakness. Serious side effects may include seizures, an increased risk of suicide in those less than 25 years of age, urinary retention, glaucoma, mania, and a number of heart issues. Nortriptyline may cause problems if taken during pregnancy. Use during breastfeeding appears to be relatively safe. It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine.
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Alpha-1 blockersAntihistaminesChemical articles with multiple CAS registry numbersDibenzocycloheptenesDrugboxes which contain changes to watched fieldsECHA InfoCard ID from WikidataHuman drug metabolitesM1 receptor antagonistsM2 receptor antagonistsM3 receptor antagonistsM4 receptor antagonistsM5 receptor antagonists