OTUD6B
Sign in to saveAlso known as DUBA-5, DUBA5, CGI-77, OTU domain containing 6B, IDDFSDA, OTU deubiquitinase 6B
OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene.
Gene data
OTUD6B- Name
- OTU deubiquitinase 6B
- Type
- protein-coding
- Aliases
- CGI-77, DUBA-5, DUBA5, IDDFSDA
This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013].
via MyGene.info
Gene · Ensembl
OTU deubiquitinase 6B
- Symbol
- OTUD6B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:91,070,196-91,087,095
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 6064
- exact match
- identifiers.org/ncbigene/51633
- genomic end
- 92099323
- genomic start
- 92082424
- cytogenetic location
- 8q21.3
Sources (4)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene.
OTUD6B is a functional deubiquitinating enzyme, a class of protease that specifically cleaves ubiquitin linkages, negating the action of ubiquitin ligases. OTUD6B, also known as DUBA5, belongs to a DUB subfamily characterized by an ovarian tumor domain (OTU). OTUD6B function may be connected to growth and proliferation. This hypothesis is supported by a recent study indicating that OTUD6B knock out mice, obtained through exon 4 deletion, are subviable and smaller in size. In humans, OTUD6B mutations have been connected to an intellectual disability syndrome associated with dysmorphic features.