SETD6

Also known as SET domain containing 6, SET domain containing 6, protein lysine methyltransferase

SET domain containing 6 is a protein in humans that is encoded by the SETD6 gene.

Gene data

SETD6

Name: SET domain containing 6, protein lysine methyltransferase
Type: protein-coding

This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

via MyGene.info

Gene · Ensembl

SET domain containing 6, protein lysine methyltransferase

Symbol: SETD6
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:58,515,479-58,523,842
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 38743
exact match: identifiers.org/ncbigene/79918
genomic end: 58523842
genomic start: 58549383
cytogenetic location: 16q21

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Further reading

SET domain containing 6 is a protein in humans that is encoded by the SETD6 gene.

SETD6 monomethylates the RelA subunit of nuclear factor kappa B (NF-κB). RelA mono-methylation at lysine 310 (RelAK310me1) leads to the constitutive repression of RelA target genes by recruiting the PKMT G9a-like protein (GLP), which catalyzes H3K9me2 and leads to chromatin silencing and gene repression. In response to stimulation with TNFa and lipopolysaccharide, phosphorylation of RelA at serine 311 (RelAS311ph) by PKCzeta physically blocks the interaction between GLP and RelAK310me1, leading to transcription activation.