Structure via PubChem · Public domain (PubChem)
oxybuprocaine
Sign in to saveAlso known as NEN891, benoxinate hydrochloride, Minims Oxybuprocaine®, Novesin, Oxyriprocaine, Oxybucaine, Butoxyaminobenzoyldiethylaminoethanol, Benoxil
Oxybuprocaine (INN), also known as benoxinate or BNX, is an ester-type local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine is sold by Novartis under the brand names Novesine or Novesin.
Chemical data
- Formula
- C17H28N2O3
- Molecular weight
- 308.4 g/mol
- IUPAC name
- 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate
- SMILES
- CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N
- InChIKey
- CMHHMUWAYWTMGS-UHFFFAOYSA-N
- XLogP
- 3.1
- Polar surface area
- 64.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- topical
- Indications
- Pruritus
via ChEMBL · EBI
Research
295 papers- Serotonin enhances oxybuprocaine- and proxymetacaine-induced cutaneous analgesia in rats.European journal of pharmacology · 2019
- Comparison of oxybuprocaine and lidocaine topical anesthesia for pain control in radiofrequency ablation treatment of great saphenous vein insufficiency.Medicine · 2023
- Comparison of Proparacaine, Tetracaine, and Oxybuprocaine in Corneal Sensitivity Measurement.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2024
- Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats.Anesthesia and analgesia · 2018
- Oxybuprocaine for apraxia of lid opening in Parkinson's disease: A placebo-controlled pilot trial.Movement disorders : official journal of the Movement Disorder Society · 2018
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 308.209993
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₇H₂₈N₂O₃
- canonical SMILES
- CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N
- World Health Organisation international non-proprietary name
- oxybuprocaine
- subject has role
- local anesthetic
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Uses
- Pharmacokinetics
- Adverse effects
- Interactions
- Synthesis
- See also
- References
Oxybuprocaine (INN), also known as benoxinate or BNX, is an ester-type local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine is sold by Novartis under the brand names Novesine or Novesin.
Safety for use in pregnancy and lactation has not been established.
Excerpted from Wikipedia’s “oxybuprocaine” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0