oxyntomodulin
Sign in to saveAlso known as OXM, GCG(53-89), OXY
Oxyntomodulin (often abbreviated OXM) is a naturally occurring 37-amino acid peptide hormone found in the colon, produced by the oxyntic (fundic) cells of the oxyntic (fundic) mucosa. It has been found to suppress appetite.
Chemical data
Drug data · ChEMBL
- Max clinical phase
- Phase 1
- Molecule type
- Protein
- Indications
- obesity, type 2 diabetes mellitus
via ChEMBL · EBI
Research
470 papers- Oxyntomodulin - past, present and future.Peptides · 2025
- Oxyntomodulin: Actions and role in diabetes.Peptides · 2018
- Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity.Peptides · 2023
- Oxyntomodulin physiology and its therapeutic development in obesity and associated complications.The Journal of physiology · 2025
- Unraveling oxyntomodulin, GLP1's enigmatic brother.The Journal of endocrinology · 2012
via PubMed
~1 min read
Encyclopedic overview
3 sectionsContents
- Research
- References
- External links
Oxyntomodulin (often abbreviated OXM) is a naturally occurring 37-amino acid peptide hormone found in the colon, produced by the oxyntic (fundic) cells of the oxyntic (fundic) mucosa. It has been found to suppress appetite.
The mechanism of action of oxyntomodulin is not well understood. It is known to bind both the GLP-1 receptor and the glucagon receptor, but it is not known whether the effects of the hormone are mediated through these receptors or through an unidentified receptor.
Excerpted from Wikipedia’s “oxyntomodulin” article, available under the CC BY-SA 4.0 licence.